Down-regulation of Cdx2 in colorectal carcinoma cells by the Raf–MEK–ERK 1/2 pathway

Cdx2 is a homeodomain transcription factor that regulates normal intestinal cell differentiation. Cdx2 is frequently lost during progression of colorectal cancer (CRC) and is widely viewed as a colorectal tumour suppressor. A previous study suggested that activation of protein kinase C (PKC) may be...

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Detalhes bibliográficos
Publicado no:Cell Signal
Main Authors: Krueger, Felix, Madeja, Zofia, Hemberger, Myriam, McMahon, Martin, Cook, Simon J., Gaunt, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4625762/
https://ncbi.nlm.nih.gov/pubmed/19686845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2009.07.020
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