GM-CSF CAUSES A PARADOXICAL INCREASE IN THE BH3-ONLY PRO-APOPTOTIC PROTEIN BIM IN HUMAN NEUTROPHILS

Neutrophil apoptosis is essential for the resolution of inflammation but delayed by several inflammatory mediators. In such terminally differentiated cells it has been uncertain whether these agents can inhibit apoptosis through transcriptional regulation of anti-death (Bcl-X(L), Mcl-1, Bcl2A1) or B...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Cowburn, Andrew S, Summers, Charlotte, Dunmore, Benjamin J, Farahi, Neda, Print, Cristin G, Cook, Simon J, Chilvers, Edwin R
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373550/
https://ncbi.nlm.nih.gov/pubmed/20705940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2010-0101OC
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