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Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7

IL-7 is pivotal for B cell development. Proteins of the Bcl-2 family are essential regulators of lymphocyte survival. Particularly, the pro-apoptotic BH3-only members Bim and Puma mediate lymphocyte apoptosis provoked by cytokine deprivation. Herein, we addressed whether the absence of Bim or Puma w...

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Autors principals: Huntington, Nicholas D., Labi, Verena, Cumano, Ana, Vieira, Paulo, Strasser, Andreas, Villunger, Andreas, Di Santo, James P., Alves, Nuno L.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2980998/
https://ncbi.nlm.nih.gov/pubmed/19454543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxp043
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