Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf

BH3 domain-only proteins (BH3-only) proteins are members of the Bcl-2 family that play crucial roles in embryogenesis and the maintenance of tissue homeostasis by triggering apoptotic cell death. The BH3-only protein Bim is critical for developmental apoptosis of lymphocytes, securing establishment...

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Hlavní autoři: Labi, Verena, Woess, Claudia, Tuzlak, Selma, Erlacher, Miriam, Bouillet, Philippe, Strasser, Andreas, Tzankov, Alexandar, Villunger, Andreas
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2014
Témata:
Hematopoiesis and Stem Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3999752/
https://ncbi.nlm.nih.gov/pubmed/24632712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-11-537217
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