Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast

Embryonic (ES) and trophoblast (TS) stem cells reflect the first, irrevocable cell fate decision in development that is reinforced by distinct epigenetic lineage barriers. Nonetheless, ES cells can seemingly acquire TS-like characteristics upon manipulation of lineage-determining transcription facto...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Cambuli, Francesco, Murray, Alexander, Dean, Wendy, Dudzinska, Dominika, Krueger, Felix, Andrews, Simon, Senner, Claire E., Cook, Simon J., Hemberger, Myriam
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Pub. Group 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263130/
https://ncbi.nlm.nih.gov/pubmed/25423963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6538
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