Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast

Embryonic (ES) and trophoblast (TS) stem cells reflect the first, irrevocable cell fate decision in development that is reinforced by distinct epigenetic lineage barriers. Nonetheless, ES cells can seemingly acquire TS-like characteristics upon manipulation of lineage-determining transcription facto...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Cambuli, Francesco, Murray, Alexander, Dean, Wendy, Dudzinska, Dominika, Krueger, Felix, Andrews, Simon, Senner, Claire E., Cook, Simon J., Hemberger, Myriam
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263130/
https://ncbi.nlm.nih.gov/pubmed/25423963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6538
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