DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome

Alterations in cerebral cortex connectivity lead to intellectual disability and in Down syndrome, this is associated with a deficit in cortical neurons that arises during prenatal development. However, the pathogenic mechanisms that cause this deficit have not yet been defined. Here we show that the...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Najas, Sònia, Arranz, Juan, Lochhead, Pamela A., Ashford, Anne L., Oxley, David, Delabar, Jean M., Cook, Simon J., Barallobre, María José, Arbonés, Maria L.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484814/
https://ncbi.nlm.nih.gov/pubmed/26137553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.01.010
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