DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome

Alterations in cerebral cortex connectivity lead to intellectual disability and in Down syndrome, this is associated with a deficit in cortical neurons that arises during prenatal development. However, the pathogenic mechanisms that cause this deficit have not yet been defined. Here we show that the...

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Pubblicato in:EBioMedicine
Autori principali: Najas, Sònia, Arranz, Juan, Lochhead, Pamela A., Ashford, Anne L., Oxley, David, Delabar, Jean M., Cook, Simon J., Barallobre, María José, Arbonés, Maria L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2015
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Original Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484814/
https://ncbi.nlm.nih.gov/pubmed/26137553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.01.010
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