The Notch-1 intracellular domain is found in sub-nuclear bodies in SH-SY5Y neuroblastomas and in primary cortical neurons

Por Hooper, Claudie, Chapple, J. Paul, Lovestone, Simon, Killick, Richard
Publicado em 2007

Focal distortion of the nuclear envelope by huntingtin aggregates revealed by lamin immunostaining

Por Chapple, J. Paul, Bros-Facer, Virginie, Butler, Rachel, Gallo, Jean-Marc
Publicado em 2008

Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium

Por Wann, Angus KT, Thompson, Clare L, Chapple, J Paul, Knight, Martin M
Publicado em 2013

Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF‐1r Onto the Primary Cilium Associated With Cilia Elongation

Por Dalbay, Melis T., Thorpe, Stephen D., Connelly, John T., Chapple, J. Paul, Knight, Martin M.
Publicado no Stem Cells (2015)

The Cytosolic Chaperone Hsc70 Promotes Traffic to the Cell Surface of Intracellular Retained Melanocortin-4 Receptor Mutants

Por Meimaridou, Eirini, Gooljar, Sakina B., Ramnarace, Nalini, Anthonypillai, Lucia, Clark, Adrian J. L., Chapple, J. Paul
Publicado no Mol Endocrinol (2011)

BiP prevents rod opsin aggregation

Por Athanasiou, Dimitra, Kosmaoglou, Maria, Kanuga, Naheed, Novoselov, Sergey S., Paton, Adrienne W., Paton, James C., Chapple, J. Paul, Cheetham, Michael E.
Publicado em 2012

Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β

Por Thompson, Clare L., Patel, Riana, Kelly, Terri-Ann N., Wann, Angus K. T., Hung, Clark T., Chapple, J. Paul, Knight, Martin M.
Publicado no Arthritis Res Ther (2015)

Deficiency of Ferritin Heavy-Chain Nuclear Import in Triple A Syndrome Implies Nuclear Oxidative Damage as the Primary Disease Mechanism

Por Storr, Helen L., Kind, Barbara, Parfitt, David A., Chapple, J. Paul, Lorenz, M., Koehler, Katrin, Huebner, Angela, Clark, Adrian J. L.
Publicado no Mol Endocrinol (2009)

Heat shock induces rapid resorption of primary cilia

Por Prodromou, Natalia V., Thompson, Clare L., Osborn, Daniel P. S., Cogger, Kathryn F., Ashworth, Rachel, Knight, Martin M., Beales, Philip L., Chapple, J. Paul
Publicado em 2012

Organization on the plasma membrane of the retinitis pigmentosa protein RP2: investigation of association with detergent-resistant membranes and polarized sorting.

Por Chapple, J Paul, Grayson, Celene, Hardcastle, Alison J, Bailey, Tracey A, Matter, Karl, Adamson, Peter, Graham, Catriona H, Willison, Keith R, Cheetham, Michael E
Publicado em 2003

A reduction in Drp1-mediated fission compromises mitochondrial health in autosomal recessive spastic ataxia of Charlevoix Saguenay

Por Bradshaw, Teisha Y., Romano, Lisa E.L., Duncan, Emma J., Nethisinghe, Suran, Abeti, Rosella, Michael, Gregory J., Giunti, Paola, Vermeer, Sascha, Chapple, J. Paul
Publicado no Hum Mol Genet (2016)

Topography of calcium phosphate ceramics regulates primary cilia length and TGF receptor recruitment associated with osteogenesis

Por Zhang, Jingwei, Dalbay, Melis T., Luo, Xiaoman, Vrij, Erik, Barbieri, Davide, Moroni, Lorenzo, de Bruijn, Joost D., van Blitterswijk, Clemens A., Chapple, J. Paul, Knight, Martin M., Yuan, Huipin
Publicado no Acta Biomater (2017)

The ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1

Por Parfitt, David A., Michael, Gregory J., Vermeulen, Esmeralda G.M., Prodromou, Natalia V., Webb, Tom R., Gallo, Jean-Marc, Cheetham, Michael E., Nicoll, William S., Blatch, Gregory L., Chapple, J. Paul
Publicado em 2009

MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family

Por Chan, Li F., Webb, Tom R., Chung, Teng-Teng, Meimaridou, Eirini, Cooray, Sadani N., Guasti, Leonardo, Chapple, J. Paul, Egertová, Michaela, Elphick, Maurice R., Cheetham, Michael E., Metherell, Louise A., Clark, Adrian J. L.
Publicado em 2009

Characterization of Aryl Hydrocarbon Receptor Interacting Protein (AIP) Mutations in Familial Isolated Pituitary Adenoma Families

Por Igreja, Susana, Chahal, Harvinder S, King, Peter, Bolger, Graeme B, Srirangalingam, Umasuthan, Guasti, Leonardo, Chapple, J Paul, Trivellin, Giampaolo, Gueorguiev, Maria, Guegan, Katie, Stals, Karen, Khoo, Bernard, Kumar, Ajith V, Ellard, Sian, Grossman, Ashley B, Korbonits, Márta
Publicado em 2010

Mutations in Nicotinamide Nucleotide Transhydrogenase (NNT) cause familial glucocorticoid deficiency

Por Meimaridou, Eirini, Kowalczyk, Julia, Guasti, Leonardo, Hughes, Claire R., Wagner, Florian, Frommolt, Peter, Nürnberg, Peter, Mann, Nicholas P., Banerjee, Ritwik, Saka, H. Nurcin, Chapple, J. Paul, King, Peter J., Clark, Adrian J.L., Metherell, Louise A.
Publicado em 2012

Mitochondrial dysfunction and Purkinje cell loss in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)

Por Girard, Martine, Larivière, Roxanne, Parfitt, David A., Deane, Emily C., Gaudet, Rebecca, Nossova, Nadya, Blondeau, Francois, Prenosil, George, Vermeulen, Esmeralda G. M., Duchen, Michael R., Richter, Andrea, Shoubridge, Eric A., Gehring, Kalle, McKinney, R. Anne, Brais, Bernard, Chapple, J. Paul, McPherson, Peter S.
Publicado em 2012