The Cytosolic Chaperone Hsc70 Promotes Traffic to the Cell Surface of Intracellular Retained Melanocortin-4 Receptor Mutants

Inherited modifications in protein structure frequently cause a loss-of-function by interfering with protein synthesis, transport, or stability. For the obesity-linked melanocortin-4 receptor (MC4R) and other G protein-coupled receptors, many mutants are intracellular retained. The biogenesis and tr...

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Detalhes bibliográficos
Publicado no:Mol Endocrinol
Main Authors: Meimaridou, Eirini, Gooljar, Sakina B., Ramnarace, Nalini, Anthonypillai, Lucia, Clark, Adrian J. L., Chapple, J. Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2011
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417233/
https://ncbi.nlm.nih.gov/pubmed/21719532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-1020
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