Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β

BACKGROUND: In osteoarthritis, chondrocytes adopt an abnormal hypertrophic morphology and upregulate the expression of the extracellular matrix-degrading enzymes, MMP-13 and ADAMTS-5. The activation of the hedgehog signalling pathway has been established in osteoarthritis and is thought to influence...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Thompson, Clare L., Patel, Riana, Kelly, Terri-Ann N., Wann, Angus K. T., Hung, Clark T., Chapple, J. Paul, Knight, Martin M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718026/
https://ncbi.nlm.nih.gov/pubmed/26705100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0891-z
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