Harnessing synthetic lethal interactions in anticancer drug discovery

ανά Chan, Denise A., Giaccia, Amato J.
Έκδοση 2011

Coordinate Regulation of the Oxygen-Dependent Degradation Domains of Hypoxia-Inducible Factor 1α

ανά Chan, Denise A., Sutphin, Patrick D., Yen, Shing-Erh, Giaccia, Amato J.
Έκδοση 2005

Hypoxia-inducible Factor-1α Stabilization in Nonhypoxic Conditions: Role of Oxidation and Intracellular Ascorbate Depletion

ανά Pagé, Elisabeth L., Chan, Denise A., Giaccia, Amato J., Levine, Mark, Richard, Darren E.
Έκδοση 2008

Identifying novel targets in renal cell carcinoma: Design and synthesis of affinity chromatography reagents

ανά Bonnet, Muriel, Flanagan, Jack U., Chan, Denise A., Giaccia, Amato J., Hay, Michael P.
Τόπος έκδοσης Bioorg Med Chem (2013)

(2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a Matrix Metalloprotease Inhibitor, Is a Novel and Potent Activator of Hypoxia-Inducible Factors

ανά Lauzier, Marie-Claude, Robitaille, Geneviève A., Chan, Denise A., Giaccia, Amato J., Richard, Darren E.
Έκδοση 2008

A molecule targeting VHL-deficient Renal Cell Carcinoma that induces autophagy

ανά Turcotte, Sandra, Chan, Denise A, Sutphin, Patrick D, Hay, Michael P, Denny, William A, Giaccia, Amato J
Έκδοση 2008

Genome-independent hypoxic repression of estrogen receptor alpha in breast cancer cells

ανά Padró, Mercè, Louie, Raymond J., Lananna, Brian V., Krieg, Adam J., Timmerman, Luika A., Chan, Denise A.
Τόπος έκδοσης BMC Cancer (2017)

Hypoxia-inducible Factor-1 Activation in Nonhypoxic Conditions: The Essential Role of Mitochondrial-derived Reactive Oxygen Species

ανά Patten, David A., Lafleur, Véronique N., Robitaille, Geneviève A., Chan, Denise A., Giaccia, Amato J., Richard, Darren E.
Έκδοση 2010

Multiple Factors Affecting Cellular Redox Status and Energy Metabolism Modulate Hypoxia-Inducible Factor Prolyl Hydroxylase Activity In Vivo and In Vitro

ανά Pan, Yi, Mansfield, Kyle D., Bertozzi, Cara C., Rudenko, Viktoriya, Chan, Denise A., Giaccia, Amato J., Simon, M. Celeste
Έκδοση 2007

Tumor Vasculature is Regulated by PHD2-mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment

ανά Chan, Denise A., Kawahara, Tiara L. A., Sutphin, Patrick D., Chang, Howard Y., Chi, Jen-Tsan, Giaccia, Amato J.
Έκδοση 2009

SAR Studies of 4-Pyridyl Heterocyclic Anilines that Selectively Induce Autophagic Cell Death in von Hippel-Lindau-Deficient Renal Cell Carcinoma Cells

ανά Bonnet, Muriel, Flanagan, Jack, U., Chan, Denise A., Lai, Edwin W., Nguyen, Phuong, Giaccia, Amato J., Hay, Michael P.
Έκδοση 2011

Distinct aerobic and hypoxic mechanisms of HIF-α regulation by CSN5

ανά Bemis, Lynne, Chan, Denise A., Finkielstein, Carla V., Qi, Lin, Sutphin, Patrick D., Chen, Xiaojiang, Stenmark, Kurt, Giaccia, Amato J., Zundel, Wayne
Έκδοση 2004

HIF-1 regulates hypoxia- and insulin-induced expression of apelin in adipocytes

ανά Glassford, Alexander J., Yue, Patrick, Sheikh, Ahmad Y., Chun, Hyung J., Zarafshar, Shirin, Chan, Denise A., Reaven, Gerald M., Quertermous, Thomas, Tsao, Philip S.
Έκδοση 2007

Toxoplasma gondii Activates Hypoxia-inducible Factor (HIF) by Stabilizing the HIF-1α Subunit via Type I Activin-like Receptor Kinase Receptor Signaling

ανά Wiley, Mandi, Sweeney, Kristin R., Chan, Denise A., Brown, Kevin M., McMurtrey, Curtis, Howard, Eric W., Giaccia, Amato J., Blader, Ira J.
Έκδοση 2010

4-Pyridylanilinothiazoles that selectively target von Hippel-Lindau deficient Renal Cell Carcinoma cells by inducing autophagic cell death

ανά Hay, Michael P., Turcotte, Sandra, Flanagan, Jack U., Bonnet, Muriel, Chan, Denise A., Sutphin, Patrick D., Nguyen, Phuong, Giaccia, Amato J., Denny, William A.
Έκδοση 2010

Molecular Imaging of Hypoxia-Inducible Factor 1α and von Hippel-Lindau Interaction in Mice

ανά Choi, Clara Y.H., Chan, Denise A., Paulmurugan, Ramasamy, Sutphin, Patrick D., Le, Quynh-Thu, Koong, Albert C., Zundel, Wayne, Gambhir, Sanjiv S., Giaccia, Amato J.
Έκδοση 2008

Tissue engineering using autologous microcirculatory beds as vascularized bioscaffolds

ανά Chang, Edward I., Bonillas, Robert G., El-ftesi, Samyra, Chang, Eric I., Ceradini, Daniel J., Vial, Ivan N., Chan, Denise A., Michaels, Joseph, Gurtner, Geoffrey C.
Έκδοση 2009

Epidermal or Dermal Specific Knockout of PHD-2 Enhances Wound Healing and Minimizes Ischemic Injury

ανά Zimmermann, Andrew S., Morrison, Shane D., Hu, Michael S., Li, Shuli, Nauta, Allison, Sorkin, Michael, Meyer, Nathaniel P., Walmsley, Graham G., Maan, Zeshaan N., Chan, Denise A., Gurtner, Geoffrey C., Giaccia, Amato J., Longaker, Michael T.
Έκδοση 2014

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple Negative Breast Tumor Therapeutic Target

ανά Timmerman, Luika A., Holton, Thomas, Yuneva, Mariia, Louie, Raymond J., Padró, Mercè, Daemen, Anneleen, Hu, Min, Chan, Denise A., Ethier, Stephen P., van ‘t Veer, Laura J., Polyak, Kornelia, McCormick, Frank, Gray, Joe W.
Έκδοση 2013

Numerical chromosomal instability mediates susceptibility to radiation treatment

ανά Bakhoum, Samuel F., Kabeche, Lilian, Wood, Matthew D., Laucius, Christopher D., Qu, Dian, Laughney, Ashley M., Reynolds, Gloria E., Louie, Raymond J., Phillips, Joanna, Chan, Denise A., Zaki, Bassem I., Murnane, John P., Petritsch, Claudia, Compton, Duane A.
Τόπος έκδοσης Nat Commun (2015)