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A molecule targeting VHL-deficient Renal Cell Carcinoma that induces autophagy
Renal Cell Carcinomas (RCCs) are refractory to standard therapies. The von Hippel-Lindau (VHL) tumor suppressor gene is inactivated in 75% of RCCs. By screening for small molecules selectively targeting VHL-deficient RCC cells, we identified STF-62247. STF-62247 induces cytotoxicity and reduces tumo...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2819422/ https://ncbi.nlm.nih.gov/pubmed/18598947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2008.06.004 |
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