A molecule targeting VHL-deficient Renal Cell Carcinoma that induces autophagy

Renal Cell Carcinomas (RCCs) are refractory to standard therapies. The von Hippel-Lindau (VHL) tumor suppressor gene is inactivated in 75% of RCCs. By screening for small molecules selectively targeting VHL-deficient RCC cells, we identified STF-62247. STF-62247 induces cytotoxicity and reduces tumo...

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Main Authors: Turcotte, Sandra, Chan, Denise A, Sutphin, Patrick D, Hay, Michael P, Denny, William A, Giaccia, Amato J
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819422/
https://ncbi.nlm.nih.gov/pubmed/18598947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2008.06.004
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