4-Pyridylanilinothiazoles that selectively target von Hippel-Lindau deficient Renal Cell Carcinoma cells by inducing autophagic cell death

Renal cell carcinomas (RCC) are refractory to standard therapy with advanced RCC having a poor prognosis; consequently treatment of advanced RCC represents an unmet clinical need. The von Hippel-Lindau (VHL) tumor suppressor gene is mutated or inactivated in a majority of RCCs. We recently identifie...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hay, Michael P., Turcotte, Sandra, Flanagan, Jack U., Bonnet, Muriel, Chan, Denise A., Sutphin, Patrick D., Nguyen, Phuong, Giaccia, Amato J., Denny, William A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838715/
https://ncbi.nlm.nih.gov/pubmed/19994864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901457w
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