4-Pyridylanilinothiazoles that selectively target von Hippel-Lindau deficient Renal Cell Carcinoma cells by inducing autophagic cell death

Renal cell carcinomas (RCC) are refractory to standard therapy with advanced RCC having a poor prognosis; consequently treatment of advanced RCC represents an unmet clinical need. The von Hippel-Lindau (VHL) tumor suppressor gene is mutated or inactivated in a majority of RCCs. We recently identifie...

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Bibliografiska uppgifter
Huvudupphovsmän: Hay, Michael P., Turcotte, Sandra, Flanagan, Jack U., Bonnet, Muriel, Chan, Denise A., Sutphin, Patrick D., Nguyen, Phuong, Giaccia, Amato J., Denny, William A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838715/
https://ncbi.nlm.nih.gov/pubmed/19994864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901457w
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