SAR Studies of 4-Pyridyl Heterocyclic Anilines that Selectively Induce Autophagic Cell Death in von Hippel-Lindau-Deficient Renal Cell Carcinoma Cells

We recently identified a class of pyridyl aniline thiazoles (PAT) that displayed selective cytotoxicity for von Hippel-Lindau (VHL) deficient renal cell carcinoma (RCC) cells in vitro and in vivo. Structure-activity relationship (SAR) studies were used to develop a Comparative Molecular Field Analys...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Bonnet, Muriel, Flanagan, Jack, U., Chan, Denise A., Lai, Edwin W., Nguyen, Phuong, Giaccia, Amato J., Hay, Michael P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3115526/
https://ncbi.nlm.nih.gov/pubmed/21561782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.04.042
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