One-Electron Reduction Potential of the Neutral Guanyl Radical in the GC Base Pair of Duplex DNA

Por Shinde, Sujata S., Maroz, Andrej, Hay, Michael P., Anderson, Robert F.
Publicado em 2009

Identifying novel targets in renal cell carcinoma: Design and synthesis of affinity chromatography reagents

Por Bonnet, Muriel, Flanagan, Jack U., Chan, Denise A., Giaccia, Amato J., Hay, Michael P.
Publicado no Bioorg Med Chem (2013)

Improved potency of the hypoxic cytotoxin tirapazamine by DNA-targeting

Por Delahoussaye, Yvette M., Hay, Michael P., Pruijn, Frederik B., Denny, William A., Brown, J. Martin
Publicado em 2003

A molecule targeting VHL-deficient Renal Cell Carcinoma that induces autophagy

Por Turcotte, Sandra, Chan, Denise A, Sutphin, Patrick D, Hay, Michael P, Denny, William A, Giaccia, Amato J
Publicado em 2008

SAR Studies of 4-Pyridyl Heterocyclic Anilines that Selectively Induce Autophagic Cell Death in von Hippel-Lindau-Deficient Renal Cell Carcinoma Cells

Por Bonnet, Muriel, Flanagan, Jack, U., Chan, Denise A., Lai, Edwin W., Nguyen, Phuong, Giaccia, Amato J., Hay, Michael P.
Publicado em 2011

4-Pyridylanilinothiazoles that selectively target von Hippel-Lindau deficient Renal Cell Carcinoma cells by inducing autophagic cell death

Por Hay, Michael P., Turcotte, Sandra, Flanagan, Jack U., Bonnet, Muriel, Chan, Denise A., Sutphin, Patrick D., Nguyen, Phuong, Giaccia, Amato J., Denny, William A.
Publicado em 2010

(18)F-EF5 PET Imaging as an Early Response Biomarker for the Hypoxia-Activated Prodrug SN30000 Combined with Radiation Treatment in a Non–Small Cell Lung Cancer Xenograft Model

Por Chitneni, Satish K., Bida, Gerald T., Yuan, Hong, Palmer, Gregory M., Hay, Michael P., Melcher, Thorsten, Wilson, William R., Zalutsky, Michael R., Dewhirst, Mark W.
Publicado em 2013

Tricyclic [1,2,4]Triazine 1,4-Dioxides As Hypoxia Selective Cytotoxins

Por Hay, Michael P., Hicks, Kevin O., Pchalek, Karin, Lee, Ho H., Blaser, Adrian, Pruijn, Frederik B., Anderson, Robert F., Shinde, Sujata S., Wilson, William R., Denny, William A.
Publicado em 2008

Pseudomonas aeruginosa NfsB and nitro-CBI-DEI – a promising enzyme/prodrug combination for gene directed enzyme prodrug therapy

Por Green, Laura K, Syddall, Sophie P, Carlin, Kendall M, Bell, Glenn D, Guise, Christopher P, Mowday, Alexandra M, Hay, Michael P, Smaill, Jeffrey B, Patterson, Adam V, Ackerley, David F
Publicado em 2013

Chemical Space Mimicry for Drug Discovery

Por Yuan, William, Jiang, Dadi, Nambiar, Dhanya K., Liew, Lydia P., Hay, Michael P., Bloomstein, Joshua, Lu, Peter, Turner, Brandon, Le, Quynh-Thu, Tibshirani, Robert, Khatri, Purvesh, Moloney, Mark G., Koong, Albert C.
Publicado no J Chem Inf Model (2017)

Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Cytotoxic to Human Multiple Myeloma

Por Jiang, Dadi, Tam, Arvin, Alagappan, Muthuraman, Hay, Michael P., Gupta, Aparna, Kozak, Margaret, Solow-Cordero, David E., Lum, Pek Y, Denko, Nicholas, Giaccia, Amato J., Le, Quynh-Thu, Niwa, Maho, Koong, Albert C.
Publicado no Mol Cancer Ther (2016)

Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogs with improved tissue penetration and hypoxic cell killing in tumors

Por Hicks, Kevin O., Siim, Bronwyn G., Jaiswal, Jagdish K., Pruijn, Frederik B., Fraser, Annie M., Patel, Rita, Hogg, Alison, Liyanage, H.D. Sarath, Jo Dorie, Mary, Brown, J. Martin, Denny, William. A., Hay, Michael P., Wilson, William R.
Publicado em 2010

Reductive Metabolism Influences the Toxicity and Pharmacokinetics of the Hypoxia-Targeted Benzotriazine Di-Oxide Anticancer Agent SN30000 in Mice

Por Gu, Yongchuan, Chang, Tony T.-A., Wang, Jingli, Jaiswal, Jagdish K., Edwards, David, Downes, Noel J., Liyanage, H. D. Sarath, Lynch, Courtney R. H., Pruijn, Frederik B., Hickey, Anthony J. R., Hay, Michael P., Wilson, William R., Hicks, Kevin O.
Publicado no Front Pharmacol (2017)

Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality

Por Chan, Denise A., Sutphin, Patrick D., Nguyen, Phuong, Turcotte, Sandra, Lai, Edwin W., Banh, Alice, Reynolds, Gloria E., Chi, Jen-Tsan, Wu, Jason, Solow-Cordero, David E., Bonnet, Muriel, Flanagan, Jack U., Bouley, Donna M., Graves, Edward E., Denny, William A., Hay, Michael P., Giaccia, Amato J.
Publicado em 2011

Dynamin impacts homology-directed repair and breast cancer response to chemotherapy

Por Chernikova, Sophia B., Nguyen, Rochelle B., Truong, Jessica T., Mello, Stephano S., Stafford, Jason H., Hay, Michael P., Olson, Andrew, Solow-Cordero, David E., Wood, Douglas J., Henry, Solomon, von Eyben, Rie, Deng, Lei, Gephart, Melanie Hayden, Aroumougame, Asaithamby, Wiese, Claudia, Game, John C., Győrffy, Balázs, Brown, J. Martin
Publicado no J Clin Invest (2018)