Pseudomonas aeruginosa NfsB and nitro-CBI-DEI – a promising enzyme/prodrug combination for gene directed enzyme prodrug therapy

BACKGROUND: The nitro-chloromethylbenzindoline prodrug nitro-CBI-DEI appears a promising candidate for the anti-cancer strategy gene-directed enzyme prodrug therapy, based on its ability to be converted to a highly cytotoxic cell-permeable derivative by the nitroreductase NfsB from Escherichia coli....

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Main Authors: Green, Laura K, Syddall, Sophie P, Carlin, Kendall M, Bell, Glenn D, Guise, Christopher P, Mowday, Alexandra M, Hay, Michael P, Smaill, Jeffrey B, Patterson, Adam V, Ackerley, David F
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2013
Assuntos:
Short Communication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3695803/
https://ncbi.nlm.nih.gov/pubmed/23758947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-12-58
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