Engineering the Escherichia coli Nitroreductase NfsA to Create a Flexible Enzyme-Prodrug Activation System

Bacterial nitroreductase enzymes that can efficiently convert nitroaromatic prodrugs to a cytotoxic form have numerous applications in targeted cellular ablation. For example, the generation of cytotoxic metabolites that have low bystander potential (i.e., are largely confined to the activating cell...

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Bibliografische gegevens
Gepubliceerd in:Front Pharmacol
Hoofdauteurs: Sharrock, Abigail V., McManaway, Sarah P., Rich, Michelle H., Mumm, Jeff S., Hermans, Ian F., Tercel, Moana, Pruijn, Frederik B., Ackerley, David F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2021
Onderwerpen:
Pharmacology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215503/
https://ncbi.nlm.nih.gov/pubmed/34163368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.701456
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