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E. coli NfsA: an alternative nitroreductase for prodrug activation gene therapy in combination with CB1954
Prodrug activation gene therapy is a developing approach to cancer treatment, whereby prodrug-activating enzymes are expressed in tumour cells. After administration of a non-toxic prodrug, its conversion to cytotoxic metabolites directly kills tumour cells expressing the activating enzyme, whereas t...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2690450/ https://ncbi.nlm.nih.gov/pubmed/19455141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605094 |
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