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The structures of E. coli NfsA bound to the antibiotic nitrofurantoin; to 1,4-benzoquinone and to FMN

NfsA is a dimeric flavoprotein that catalyses the reduction in nitroaromatics and quinones by NADPH. This reduction is required for the activity of nitrofuran antibiotics. The crystal structure of free Escherichia coli NfsA and several homologues have been determined previously, but there is no stru...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Biochem J
Main Authors: Day, Martin A., Jarrom, David, Christofferson, Andrew J., Graziano, Antonio E., Anderson, J. L. Ross, Searle, Peter F., Hyde, Eva I., White, Scott A.
Format: Artigo
Jezik:Inglês
Izdano: Portland Press Ltd. 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8286842/
https://ncbi.nlm.nih.gov/pubmed/34142705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20210160
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