The structures of E. coli NfsA bound to the antibiotic nitrofurantoin; to 1,4-benzoquinone and to FMN

NfsA is a dimeric flavoprotein that catalyses the reduction in nitroaromatics and quinones by NADPH. This reduction is required for the activity of nitrofuran antibiotics. The crystal structure of free Escherichia coli NfsA and several homologues have been determined previously, but there is no stru...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Day, Martin A., Jarrom, David, Christofferson, Andrew J., Graziano, Antonio E., Anderson, J. L. Ross, Searle, Peter F., Hyde, Eva I., White, Scott A.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2021
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8286842/
https://ncbi.nlm.nih.gov/pubmed/34142705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20210160
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