The structures of E. coli NfsA bound to the antibiotic nitrofurantoin; to 1,4-benzoquinone and to FMN

NfsA is a dimeric flavoprotein that catalyses the reduction in nitroaromatics and quinones by NADPH. This reduction is required for the activity of nitrofuran antibiotics. The crystal structure of free Escherichia coli NfsA and several homologues have been determined previously, but there is no stru...

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Publicado en:Biochem J
Autores principales: Day, Martin A., Jarrom, David, Christofferson, Andrew J., Graziano, Antonio E., Anderson, J. L. Ross, Searle, Peter F., Hyde, Eva I., White, Scott A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Portland Press Ltd. 2021
Materias:
Enzymology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8286842/
https://ncbi.nlm.nih.gov/pubmed/34142705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20210160
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