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The Flavin Reductase MsuE Is a Novel Nitroreductase that Can Efficiently Activate Two Promising Next-Generation Prodrugs for Gene-Directed Enzyme Prodrug Therapy

Bacterial nitroreductase enzymes that can efficiently catalyse the oxygen-independent reduction of prodrugs originally developed to target tumour hypoxia offer great potential for expanding the therapeutic range of these molecules to aerobic tumour regions, via the emerging cancer strategy of gene-d...

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Detalhes bibliográficos
Main Authors: Green, Laura K., Storey, Mathew A., Williams, Elsie M., Patterson, Adam V., Smaill, Jeff B., Copp, Janine N., Ackerley, David F.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795375/
https://ncbi.nlm.nih.gov/pubmed/24202330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers5030985
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