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HIF-1 regulates hypoxia- and insulin-induced expression of apelin in adipocytes
Apelin, a novel peptide with significant cardioactive properties, is upregulated by insulin in adipocytes. However, the mechanism by which insulin promotes apelin production is unknown. Hypoxia-inducible factor-1 (HIF-1), a heterodimeric transcription factor involved in the angiogenic and metabolic...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2570255/ https://ncbi.nlm.nih.gov/pubmed/17878221 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00490.2007 |
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