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In vivo Genetic Profiling and Cellular Localization of Apelin Reveals a Hypoxia-Sensitive, Endothelial-Centered Pathway Activated In Ischemic Heart Failure

Signaling by the peptide ligand apelin and its cognate G-protein coupled receptor APJ has a potent inotropic effect on cardiac contractility and modulates systemic vascular resistance through nitric oxide dependent signaling. In addition, there is evidence for counter-regulation of the angiotensin a...

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Detalhes bibliográficos
Main Authors: Sheikh, Ahmad Y, Chun, Hyung J, Glassford, Alexander J, Kundu, Ramendera K, Kutschka, Ingo, Ardigo, Diego, Hendry, Stephen L, Wagner, Roger A., Chen, Mary M., Ali, Ziad A., Yue, Patrick, Huynh, Diem T., Connolly, Andrew J, Pelletier, Marc P, Tsao, Phil, Robbins, Robert C, Quertermous, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570026/
https://ncbi.nlm.nih.gov/pubmed/17906101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00935.2007
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