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Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis

Apelin and its cognate G protein–coupled receptor APJ constitute a signaling pathway with a positive inotropic effect on cardiac function and a vasodepressor function in the systemic circulation. The apelin-APJ pathway appears to have opposing physiological roles to the renin-angiotensin system. Her...

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Detalhes bibliográficos
Main Authors: Chun, Hyung J., Ali, Ziad A., Kojima, Yoko, Kundu, Ramendra K., Sheikh, Ahmad Y., Agrawal, Rani, Zheng, Lixin, Leeper, Nicholas J., Pearl, Nathan E., Patterson, Andrew J., Anderson, Joshua P., Tsao, Philip S., Lenardo, Michael J., Ashley, Euan A., Quertermous, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2525695/
https://ncbi.nlm.nih.gov/pubmed/18769630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34871
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