Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis

Apelin and its cognate G protein–coupled receptor APJ constitute a signaling pathway with a positive inotropic effect on cardiac function and a vasodepressor function in the systemic circulation. The apelin-APJ pathway appears to have opposing physiological roles to the renin-angiotensin system. Her...

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Bibliografske podrobnosti
Main Authors: Chun, Hyung J., Ali, Ziad A., Kojima, Yoko, Kundu, Ramendra K., Sheikh, Ahmad Y., Agrawal, Rani, Zheng, Lixin, Leeper, Nicholas J., Pearl, Nathan E., Patterson, Andrew J., Anderson, Joshua P., Tsao, Philip S., Lenardo, Michael J., Ashley, Euan A., Quertermous, Thomas
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2008
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2525695/
https://ncbi.nlm.nih.gov/pubmed/18769630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34871
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