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Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis
Apelin and its cognate G protein–coupled receptor APJ constitute a signaling pathway with a positive inotropic effect on cardiac function and a vasodepressor function in the systemic circulation. The apelin-APJ pathway appears to have opposing physiological roles to the renin-angiotensin system. Her...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Clinical Investigation
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2525695/ https://ncbi.nlm.nih.gov/pubmed/18769630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34871 |
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