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Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis

Apelin and its cognate G protein–coupled receptor APJ constitute a signaling pathway with a positive inotropic effect on cardiac function and a vasodepressor function in the systemic circulation. The apelin-APJ pathway appears to have opposing physiological roles to the renin-angiotensin system. Her...

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Bibliografiske detaljer
Main Authors: Chun, Hyung J., Ali, Ziad A., Kojima, Yoko, Kundu, Ramendra K., Sheikh, Ahmad Y., Agrawal, Rani, Zheng, Lixin, Leeper, Nicholas J., Pearl, Nathan E., Patterson, Andrew J., Anderson, Joshua P., Tsao, Philip S., Lenardo, Michael J., Ashley, Euan A., Quertermous, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2525695/
https://ncbi.nlm.nih.gov/pubmed/18769630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34871
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