Disruption of the Apelin-APJ System Worsens Hypoxia-Induced Pulmonary Hypertension

OBJECTIVE: The G-protein–coupled receptor APJ and its ligand apelin are highly expressed in the pulmonary vasculature, but their function in this vascular bed is unclear. We hypothesized that disruption of apelin signaling would lead to worsening of the vascular remodeling associated with pulmonary...

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Main Authors: Chandra, Suparna M., Razavi, Hedi, Kim, Jongmin, Agrawal, Rani, Kundu, Ramendra, de Jesus Perez, Vinicio, Zamanian, Roham T., Quertermous, Thomas, Chun, Hyung J.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113525/
https://ncbi.nlm.nih.gov/pubmed/21233449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.219980
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