In vivo Genetic Profiling and Cellular Localization of Apelin Reveals a Hypoxia-Sensitive, Endothelial-Centered Pathway Activated In Ischemic Heart Failure

Signaling by the peptide ligand apelin and its cognate G-protein coupled receptor APJ has a potent inotropic effect on cardiac contractility and modulates systemic vascular resistance through nitric oxide dependent signaling. In addition, there is evidence for counter-regulation of the angiotensin a...

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Hlavní autoři: Sheikh, Ahmad Y, Chun, Hyung J, Glassford, Alexander J, Kundu, Ramendera K, Kutschka, Ingo, Ardigo, Diego, Hendry, Stephen L, Wagner, Roger A., Chen, Mary M., Ali, Ziad A., Yue, Patrick, Huynh, Diem T., Connolly, Andrew J, Pelletier, Marc P, Tsao, Phil, Robbins, Robert C, Quertermous, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570026/
https://ncbi.nlm.nih.gov/pubmed/17906101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00935.2007
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