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In vivo Genetic Profiling and Cellular Localization of Apelin Reveals a Hypoxia-Sensitive, Endothelial-Centered Pathway Activated In Ischemic Heart Failure

Signaling by the peptide ligand apelin and its cognate G-protein coupled receptor APJ has a potent inotropic effect on cardiac contractility and modulates systemic vascular resistance through nitric oxide dependent signaling. In addition, there is evidence for counter-regulation of the angiotensin a...

詳細記述

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書誌詳細
主要な著者: Sheikh, Ahmad Y, Chun, Hyung J, Glassford, Alexander J, Kundu, Ramendera K, Kutschka, Ingo, Ardigo, Diego, Hendry, Stephen L, Wagner, Roger A., Chen, Mary M., Ali, Ziad A., Yue, Patrick, Huynh, Diem T., Connolly, Andrew J, Pelletier, Marc P, Tsao, Phil, Robbins, Robert C, Quertermous, Thomas
フォーマット: Artigo
言語:Inglês
出版事項: 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570026/
https://ncbi.nlm.nih.gov/pubmed/17906101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00935.2007
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