Toxoplasma gondii Activates Hypoxia-inducible Factor (HIF) by Stabilizing the HIF-1α Subunit via Type I Activin-like Receptor Kinase Receptor Signaling

Toxoplasma gondii is an intracellular protozoan parasite that can cause devastating disease in fetuses and immune-compromised individuals. We previously reported that the α subunit of the host cell transcription factor, hypoxia-inducible factor-1 (HIF-1), is up-regulated by infection and necessary f...

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Главные авторы: Wiley, Mandi, Sweeney, Kristin R., Chan, Denise A., Brown, Kevin M., McMurtrey, Curtis, Howard, Eric W., Giaccia, Amato J., Blader, Ira J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2010
Предметы:
Signal Transduction
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930684/
https://ncbi.nlm.nih.gov/pubmed/20581113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.147041
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