Role of transcription-regulating kinase CDK8 in colon cancer metastasis

по Liang, Jiaxin, Chen, Mengqian, Broude, Eugenia V., Roninson, Igor B.
Опубликовано в: Oncotarget (2019)

Cellular Model of p21-Induced Senescence

по Shtutman, Michael, Chang, Bey-Dih, Schools, Gary P., Broude, Eugenia V.
Опубликовано в: Methods Mol Biol (2017)

Characterizing CDK8/19 Inhibitors through a NFκB-Dependent Cell-Based Assay

по Li, Jing, Ji, Hao, Porter, Donald C., Broude, Eugenia V., Roninson, Igor B., Chen, Mengqian
Опубликовано в: Cells (2019)

Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent

по Chang, Bey-Dih, Swift, Mari E., Shen, Mei, Fang, Jing, Broude, Eugenia V., Roninson, Igor B.
Опубликовано 2002

Systemic Toxicity Reported for CDK8/19 Inhibitors CCT251921 and MSC2530818 Is Not Due to Target Inhibition

по Chen, Mengqian, Li, Jing, Liang, Jiaxin, Thompson, Zanshé S., Kathrein, Katie, Broude, Eugenia V., Roninson, Igor B.
Опубликовано в: Cells (2019)

Identifying Cancers Impacted by CDK8/19

по Roninson, Igor B., Győrffy, Balázs, Mack, Zachary T., Shtil, Alexander A., Shtutman, Michael S., Chen, Mengqian, Broude, Eugenia V.
Опубликовано в: Cells (2019)

Effects of p21(Waf1/Cip1/Sdi1) on cellular gene expression: Implications for carcinogenesis, senescence, and age-related diseases

по Chang, Bey-Dih, Watanabe, Keiko, Broude, Eugenia V., Fang, Jing, Poole, Jason C., Kalinichenko, Tatiana V., Roninson, Igor B.
Опубликовано 2000

CDK7 Inhibition Is Effective in all the Subtypes of Breast Cancer: Determinants of Response and Synergy with EGFR Inhibition

по McDermott, Martina S. J., Sharko, Amanda C., Munie, Jessica, Kassler, Susannah, Melendez, Theresa, Lim, Chang-uk, Broude, Eugenia V.
Опубликовано в: Cells (2020)

Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer

по Broude, Eugenia V., Győrffy, Balázs, Chumanevich, Alexander A., Chen, Mengqian, McDermott, Martina S. J., Shtutman, Michael, Catroppo, James F., Roninson, Igor B.
Опубликовано в: Curr Cancer Drug Targets (2015)

Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1

по Alam, Amer, Küng, Raphael, Kowal, Julia, McLeod, Robert A., Tremp, Nina, Broude, Eugenia V., Roninson, Igor B., Stahlberg, Henning, Locher, Kaspar P.
Опубликовано в: Proc Natl Acad Sci U S A (2018)

Function-based gene identification using enzymatically generated normalized shRNA library and massive parallel sequencing

по Shtutman, Michael, Maliyekkel, Anil, Shao, Yu, Carmack, C. Steven, Baig, Mirza, Warholic, Natalie, Cole, Kelly, Broude, Eugenia V., Harkins, Timothy T., Ding, Ye, Roninson, Igor B.
Опубликовано 2010

Effects of conditional depletion of topoisomerase II on cell cycle progression in mammalian cells

по Gonzalez, Ruth E, Lim, Chang-Uk, Cole, Kelly, Bianchini, Christine Hanko, Schools, Gary P, Davis, Brian E, Wada, Ikuo, Roninson, Igor B, Broude, Eugenia V
Опубликовано 2011

Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer

по Serrao, Anne, Jenkins, Laura M., Chumanevich, Alexander A., Horst, Ben, Liang, Jiaxin, Gatza, Michael L., Lee, Nam Y., Roninson, Igor B., Broude, Eugenia V., Mythreye, Karthikeyan
Опубликовано в: Oncogene (2018)

The Inhibition of CDK8/19 Mediator Kinases Prevents the Development of Resistance to EGFR-Targeting Drugs

по Sharko, Amanda C., Lim, Chang-Uk, McDermott, Martina S. J., Hennes, Chuck, Philavong, Kingsavanh P., Aiken, Tiffanie, Tatarskiy, Victor V., Roninson, Igor B., Broude, Eugenia V.
Опубликовано в: Cells (2021)

Inhibin is a novel paracrine factor for tumor angiogenesis and metastasis

по Singh, Priyanka, Jenkins, Laura M., Horst, Ben, Alers, Victoria, Pradhan, Shrikant, Kaur, Prabhjot, Srivastava, Tapasya, Hempel, Nadine, Győrffy, Balázs, Broude, Eugenia V., Lee, Nam Y., Mythreye, Karthikeyan
Опубликовано в: Cancer Res (2018)

CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix metalloproteinases

по Liang, Jiaxin, Chen, Mengqian, Hughes, Daniel, Chumanevich, Alexander A., Altilia, Serena, Kaza, Vimala, Lim, Chang-Uk, Kiaris, Hippokratis, Mythreye, Karthikeyan, Pena, Maria Marjorette, Broude, Eugenia V., Roninson, Igor B.
Опубликовано в: Cancer Res (2018)

Identification of novel genes that regulate androgen receptor signaling and growth of androgen-deprived prostate cancer cells

по Levina, Elina, Ji, Hao, Chen, Mengqiang, Baig, Mirza, Oliver, David, Ohouo, Patrice, Lim, Chang-uk, Schools, Garry, Carmack, Steven, Ding, Ye, Broude, Eugenia V., Roninson, Igor B., Buttyan, Ralph, Shtutman, Michael
Опубликовано в: Oncotarget (2015)

Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer

по McDermott, Martina S.J., Chumanevich, Alexander A., Lim, Chang-uk, Liang, Jiaxin, Chen, Mengqian, Altilia, Serena, Oliver, David, Rae, James M., Shtutman, Michael, Kiaris, Hippokratis, Győrffy, Balázs, Roninson, Igor B., Broude, Eugenia V.
Опубликовано в: Oncotarget (2017)

CDK8/19 Mediator kinases potentiate induction of transcription by NFκB

по Chen, Mengqian, Liang, Jiaxin, Ji, Hao, Yang, Zhengguan, Altilia, Serena, Hu, Bing, Schronce, Adam, McDermott, Martina S. J., Schools, Gary P., Lim, Chang-uk, Oliver, David, Shtutman, Michael S., Lu, Tao, Stark, George R., Porter, Donald C., Broude, Eugenia V., Roninson, Igor B.
Опубликовано в: Proc Natl Acad Sci U S A (2017)

Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities

по Porter, Donald C., Farmaki, Elena, Altilia, Serena, Schools, Gary P., West, Deborah K., Chen, Mengqian, Chang, Bey-Dih, Puzyrev, Anatoliy T., Lim, Chang-uk, Rokow-Kittell, Rebecca, Friedhoff, Lawrence T., Papavassiliou, Athanasios G., Kalurupalle, Swathi, Hurteau, Gregory, Shi, Jun, Baran, Phil S., Gyorffy, Balazs, Wentland, Mark P., Broude, Eugenia V., Kiaris, Hippokratis, Roninson, Igor B.
Опубликовано 2012