Effects of conditional depletion of topoisomerase II on cell cycle progression in mammalian cells

Topoisomerase II (Topo II) that decatenates newly synthesized DNA is targeted by many anticancer drugs. Some of these drugs stabilize intermediate complexes of DNA with Topo II and others act as catalytic inhibitors of Topo II. Simultaneous depletion of Topo IIα and Topo IIβ, the two isoforms of mam...

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Bibliografiske detaljer
Main Authors: Gonzalez, Ruth E, Lim, Chang-Uk, Cole, Kelly, Bianchini, Christine Hanko, Schools, Gary P, Davis, Brian E, Wada, Ikuo, Roninson, Igor B, Broude, Eugenia V
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2011
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356834/
https://ncbi.nlm.nih.gov/pubmed/22067657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.20.17778
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