CDK8/19 Mediator kinases potentiate induction of transcription by NFκB

The nuclear factor-κB (NFκB) family of transcription factors has been implicated in inflammatory disorders, viral infections, and cancer. Most of the drugs that inhibit NFκB show significant side effects, possibly due to sustained NFκB suppression. Drugs affecting induced, but not basal, NFκB activi...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Chen, Mengqian, Liang, Jiaxin, Ji, Hao, Yang, Zhengguan, Altilia, Serena, Hu, Bing, Schronce, Adam, McDermott, Martina S. J., Schools, Gary P., Lim, Chang-uk, Oliver, David, Shtutman, Michael S., Lu, Tao, Stark, George R., Porter, Donald C., Broude, Eugenia V., Roninson, Igor B.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617299/
https://ncbi.nlm.nih.gov/pubmed/28855340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710467114
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