CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix metalloproteinases

Unresectable hepatic metastases of colon cancer respond poorly to existing therapies and are a major cause of colon cancer lethality. In this study, we evaluated the therapeutic viability of targeting the Mediator kinase CDK8, an early clinical stage drug target, as a means to suppress metastasis of...

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Bibliografiske detaljer
Udgivet i:Cancer Res
Main Authors: Liang, Jiaxin, Chen, Mengqian, Hughes, Daniel, Chumanevich, Alexander A., Altilia, Serena, Kaza, Vimala, Lim, Chang-Uk, Kiaris, Hippokratis, Mythreye, Karthikeyan, Pena, Maria Marjorette, Broude, Eugenia V., Roninson, Igor B.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279600/
https://ncbi.nlm.nih.gov/pubmed/30185549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-1583
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