CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix metalloproteinases

Unresectable hepatic metastases of colon cancer respond poorly to existing therapies and are a major cause of colon cancer lethality. In this study, we evaluated the therapeutic viability of targeting the Mediator kinase CDK8, an early clinical stage drug target, as a means to suppress metastasis of...

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Bibliografische gegevens
Gepubliceerd in:Cancer Res
Hoofdauteurs: Liang, Jiaxin, Chen, Mengqian, Hughes, Daniel, Chumanevich, Alexander A., Altilia, Serena, Kaza, Vimala, Lim, Chang-Uk, Kiaris, Hippokratis, Mythreye, Karthikeyan, Pena, Maria Marjorette, Broude, Eugenia V., Roninson, Igor B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279600/
https://ncbi.nlm.nih.gov/pubmed/30185549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-1583
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