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Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer
CDK8 is a transcription-regulating kinase that controls TGF-β/BMP-responsive SMAD transcriptional activation and turnover through YAP1 recruitment. However, how the CDK8/YAP1 pathway influences SMAD1 response in cancer remains unclear. Here we report that SMAD1-driven epithelial-to-mesenchymal trans...
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| Publicado no: | Oncogene |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7018387/ https://ncbi.nlm.nih.gov/pubmed/29780169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0316-y |
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