Effects of p21(Waf1/Cip1/Sdi1) on cellular gene expression: Implications for carcinogenesis, senescence, and age-related diseases

Induction of cyclin-dependent kinase inhibitor p21(Waf1/Cip1/Sdi1) triggers cell growth arrest associated with senescence and damage response. Overexpression of p21 from an inducible promoter in a human cell line induces growth arrest and phenotypic features of senescence. cDNA array hybridization s...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Chang, Bey-Dih, Watanabe, Keiko, Broude, Eugenia V., Fang, Jing, Poole, Jason C., Kalinichenko, Tatiana V., Roninson, Igor B.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18232/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10760295/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.8.4291
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