Structure and mechanism of ATP-binding cassette transporters

Por Locher, Kaspar P.
Publicado em 2008

Structure of the human transcobalamin beta domain in four distinct states

Por Bloch, Joël S., Ruetz, Markus, Kräutler, Bernhard, Locher, Kaspar P.
Publicado no PLoS One (2017)

A distinct mechanism for the ABC transporter BtuCD-F revealed by the dynamics of complex formation

Por Lewinson, Oded, Lee, Allen T., Locher, Kaspar P., Rees, Douglas C.
Publicado em 2010

The structure of Escherichia coli BtuF and binding to its cognate ATP binding cassette transporter

Por Borths, Elizabeth L., Locher, Kaspar P., Lee, Allen T., Rees, Douglas C.
Publicado em 2002

Structural insight into substrate and inhibitor discrimination by human P-glycoprotein

Por Alam, Amer, Kowal, Julia, Broude, Eugenia, Roninson, Igor, Locher, Kaspar P.
Publicado no Science (2019)

Transmembrane Gate Movements in the Type II ATP-binding Cassette (ABC) Importer BtuCD-F during Nucleotide Cycle

Por Joseph, Benesh, Jeschke, Gunnar, Goetz, Birke A., Locher, Kaspar P., Bordignon, Enrica
Publicado em 2011

Structure of bacterial oligosaccharyltransferase PglB bound to a reactive LLO and an inhibitory peptide

Por Napiórkowska, Maja, Boilevin, Jérémy, Darbre, Tamis, Reymond, Jean-Louis, Locher, Kaspar P.
Publicado no Sci Rep (2018)

In Vitro Folding and Assembly of the Escherichia coli ATP-binding Cassette Transporter, BtuCD

Por Di Bartolo, Natalie D., Hvorup, Rikki N., Locher, Kaspar P., Booth, Paula J.
Publicado em 2011

Structural basis of inhibition of lipid-linked oligosaccharide flippase PglK by a conformational nanobody

Por Perez, Camilo, Köhler, Martin, Janser, Daniel, Pardon, Els, Steyaert, Jan, Zenobi, Renato, Locher, Kaspar P.
Publicado no Sci Rep (2017)

Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states

Por Manolaridis, Ioannis, Jackson, Scott M., Taylor, Nicholas M. I., Kowal, Julia, Stahlberg, Henning, Locher, Kaspar P.
Publicado no Nature (2018)

Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1

Por Nosol, Kamil, Romane, Ksenija, Irobalieva, Rossitza N., Alam, Amer, Kowal, Julia, Fujita, Naoya, Locher, Kaspar P.
Publicado no Proc Natl Acad Sci U S A (2020)

Structural basis of the molecular ruler mechanism of a bacterial glycosyltransferase

Por Ramírez, Ana S., Boilevin, Jérémy, Mehdipour, Ahmad Reza, Hummer, Gerhard, Darbre, Tamis, Reymond, Jean-Louis, Locher, Kaspar P.
Publicado no Nat Commun (2018)

Mechanism of Bacterial Oligosaccharyltransferase: IN VITRO QUANTIFICATION OF SEQUON BINDING AND CATALYSIS

Por Gerber, Sabina, Lizak, Christian, Michaud, Gaëlle, Bucher, Monika, Darbre, Tamis, Aebi, Markus, Reymond, Jean-Louis, Locher, Kaspar P.
Publicado em 2013

Structural basis of transcobalamin recognition by human CD320 receptor

Por Alam, Amer, Woo, Jae-Sung, Schmitz, Jennifer, Prinz, Bernadette, Root, Katharina, Chen, Fan, Bloch, Joël S., Zenobi, Renato, Locher, Kaspar P.
Publicado no Nat Commun (2016)

Characterization of the single-subunit oligosaccharyltransferase STT3A from Trypanosoma brucei using synthetic peptides and lipid-linked oligosaccharide analogs

Por Ramírez, Ana S, Boilevin, Jérémy, Biswas, Rasomoy, Gan, Bee Ha, Janser, Daniel, Aebi, Markus, Darbre, Tamis, Reymond, Jean-Louis, Locher, Kaspar P
Publicado no Glycobiology (2017)

Chemo-enzymatic synthesis of lipid-linked GlcNAc(2)Man(5) oligosaccharides using recombinant Alg1, Alg2 and Alg11 proteins

Por Ramírez, Ana S, Boilevin, Jérémy, Lin, Chia-Wei, Ha Gan, Bee, Janser, Daniel, Aebi, Markus, Darbre, Tamis, Reymond, Jean-Louis, Locher, Kaspar P
Publicado no Glycobiology (2017)

Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1

Por Alam, Amer, Küng, Raphael, Kowal, Julia, McLeod, Robert A., Tremp, Nina, Broude, Eugenia V., Roninson, Igor B., Stahlberg, Henning, Locher, Kaspar P.
Publicado no Proc Natl Acad Sci U S A (2018)

A Catalytically Essential Motif in External Loop 5 of the Bacterial Oligosaccharyltransferase PglB

Por Lizak, Christian, Gerber, Sabina, Zinne, Daria, Michaud, Gaëlle, Schubert, Mario, Chen, Fan, Bucher, Monika, Darbre, Tamis, Zenobi, Renato, Reymond, Jean-Louis, Locher, Kaspar P.
Publicado em 2014