Mechanism of Bacterial Oligosaccharyltransferase: IN VITRO QUANTIFICATION OF SEQUON BINDING AND CATALYSIS

N-Linked glycosylation is an essential post-translational protein modification in the eukaryotic cell. The initial transfer of an oligosaccharide from a lipid carrier onto asparagine residues within a consensus sequon is catalyzed by oligosaccharyltransferase (OST). The first X-ray structure of a co...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Gerber, Sabina, Lizak, Christian, Michaud, Gaëlle, Bucher, Monika, Darbre, Tamis, Aebi, Markus, Reymond, Jean-Louis, Locher, Kaspar P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Glycobiology and Extracellular Matrices
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610960/
https://ncbi.nlm.nih.gov/pubmed/23382388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.445940
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