Manganese and Microbial Pathogenesis: Sequestration by the Mammalian Immune System and Utilization by Microorganisms

Por Brophy, Megan Brunjes, Nolan, Elizabeth M.
Publicado no ACS Chem Biol (2015)

Calcium Ion Gradients Modulate the Zinc Affinity and Antibacterial Activity of Human Calprotectin

Por Brophy, Megan Brunjes, Hayden, Joshua A., Nolan, Elizabeth M.
Publicado em 2012

High-affinity Manganese Coordination by Human Calprotectin is Calcium-dependent and Requires the Histidine-rich Site Formed at the Dimer Interface

Por Hayden, Joshua A., Brophy, Megan Brunjes, Cunden, Lisa S., Nolan, Elizabeth M.
Publicado em 2012

Contributions of the S100A9 C-Terminal Tail to High-Affinity Mn(II) Chelation by the Host-Defense Protein Human Calprotectin

Por Brophy, Megan Brunjes, Nakashige, Toshiki G., Gaillard, Aleth, Nolan, Elizabeth M.
Publicado em 2013

Biochemical and Functional Evaluation of the Intramolecular Disulfide Bonds in the Zinc-Chelating Antimicrobial Protein Human S100A7 (Psoriasin)

Por Cunden, Lisa S., Brophy, Megan Brunjes, Rodriguez, Grayson E., Flaxman, Hope A., Nolan, Elizabeth M.
Publicado no Biochemistry (2017)

Eating the Dead to Keep Atherosclerosis at Bay

Por Brophy, Megan L., Dong, Yunzhou, Wu, Hao, Rahman, H. N. Ashiqur, Song, Kai, Chen, Hong
Publicado no Front Cardiovasc Med (2017)

Biochemical and Spectroscopic Observation of Mn(II) Transfer Between Bacterial Mn(II) Transport Machinery and Calprotectin

Por Hadley, Rose C., Gagnon, Derek M., Brophy, Megan Brunjes, Gu, Yu, Nakashige, Toshiki G., Britt, R. David, Nolan, Elizabeth M.
Publicado no J Am Chem Soc (2017)

Manganese Binding Properties of Human Calprotectin Under Conditions of High and Low Calcium: X-ray Crystallographic and Advanced EPR Spectroscopic Analysis

Por Gagnon, Derek M., Brophy, Megan Brunjes, Bowman, Sarah E. J., Stich, Troy A., Drennan, Catherine L., Britt, R. David, Nolan, Elizabeth M.
Publicado no J Am Chem Soc (2015)

The Hexahistidine Motif of Host-Defense Protein Human Calprotectin Contributes to Zinc Withholding and Its Functional Versatility

Por Nakashige, Toshiki G., Stephan, Jules R., Cunden, Lisa S., Brophy, Megan Brunjes, Wommack, Andrew J., Keegan, Brenna C., Shearer, Jason M., Nolan, Elizabeth M.
Publicado no J Am Chem Soc (2016)

Endothelial epsins as regulators and potential therapeutic targets of tumor angiogenesis

Por Song, Kai, Wu, Hao, Rahman, H. N. Ashiqur, Dong, Yunzhou, Wen, Aiyun, Brophy, Megan L., Wong, Scott, Kwak, Sukyoung, Bielenberg, Diane R., Chen, Hong
Publicado no Cell Mol Life Sci (2016)

Role of endoplasmic reticulum stress signalling in diabetic endothelial dysfunction and atherosclerosis

Por Dong, Yunzhou, Fernandes, Conrad, Liu, Yanjun, Wu, Yong, Wu, Hao, Brophy, Megan L, Deng, Lin, Song, Kai, Wen, Aiyun, Wong, Scott, Yan, Daoguang, Towner, Rheal, Chen, Hong
Publicado no Diab Vasc Dis Res (2016)

The Roles of the A and C Sites in the Manganese-Specific Activation of MntR

Por McGuire, Amanda M., Cuthbert, Bonnie J., Ma, Zhen, Grauer-Gray, Kristen D., Brophy, Megan B., Spear, Kayce A., Soonsanga, Sumarin, Kliegman, Joseph I., Griner, Sarah L., Helmann, John D., Glasfeld, Arthur
Publicado em 2013

Impaired cholecystokinin-induced gallbladder emptying incriminated in spontaneous “black” pigment gallstone formation in germfree Swiss Webster mice

Por Woods, Stephanie E., Leonard, Monika R., Hayden, Joshua A., Brophy, Megan Brunjes, Bernert, Kara R., Lavoie, Brigitte, Muthupalani, Sureshkumar, Whary, Mark T., Mawe, Gary M., Nolan, Elizabeth M., Carey, Martin C., Fox, James G.
Publicado no Am J Physiol Gastrointest Liver Physiol (2014)

Epsin is required for Dishevelled stability and Wnt signaling activation in colon cancer development

Por Chang, Baojun, Tessneer, Kandice L., McManus, John, Liu, Xiaolei, Hahn, Scott, Pasula, Satish, Wu, Hao, Song, Hoogeun, Chen, Yiyuan, Cai, Xiaofeng, Dong, Yunzhou, Brophy, Megan L., Rahman, Ruby, Ma, Jian-Xing, Xia, Lijun, Chen, Hong
Publicado no Nat Commun (2015)

Temporal and Spatial Regulation of Epsin Abundance and VEGFR3 Signaling are Required for Lymphatic Valve Formation and Function

Por Liu, Xiaolei, Pasula, Satish, Song, Hoogeun, Tessneer, Kandice L., Dong, Yunzhou, Hahn, Scott, Yago, Tadayuki, Brophy, Megan, Chang, Baojun, Cai, Xiaofeng, Wu, Hao, McManus, John, Ichise, Hirotake, Georgescu, Constantin, Wren, Jonathan D., Griffin, Courtney, Xia, Lijun, Srinivasan, R. Sathish, Chen, Hong
Publicado no Sci Signal (2014)

Selective Targeting of a Novel Epsin-VEGFR2 Interaction Promotes VEGF-Mediated Angiogenesis

Por Rahman, H. N. Ashiqur, Wu, Hao, Dong, Yunzhou, Pasula, Satish, Wen, Aiyun, Sun, Ye, Brophy, Megan L., Tessneer, Kandice L., Cai, Xiaofeng, McManus, John, Chang, Baojun, Kwak, Sukyoung, Rahman, Negar S., Xu, Wenjia, Fernandes, Conrad, Mcdaniel, John Michael, Xia, Lijun, Smith, Lois, Srinivasan, R. Sathish, Chen, Hong
Publicado no Circ Res (2016)

Epsin deficiency promotes lymphangiogenesis through regulation of VEGFR3 degradation in diabetes

Por Wu, Hao, Rahman, H.N. Ashiqur, Dong, Yunzhou, Liu, Xiaolei, Lee, Yang, Wen, Aiyun, To, Kim H.T., Xiao, Li, Birsner, Amy E., Bazinet, Lauren, Wong, Scott, Song, Kai, Brophy, Megan L., Mahamud, M. Riaj, Chang, Baojun, Cai, Xiaofeng, Pasula, Satish, Kwak, Sukyoung, Yang, Wenxia, Bischoff, Joyce, Xu, Jian, Bielenberg, Diane R., Dixon, J. Brandon, D’Amato, Robert J., Srinivasan, R. Sathish, Chen, Hong
Publicado no J Clin Invest (2018)

Motif mimetic of epsin perturbs tumor growth and metastasis

Por Dong, Yunzhou, Wu, Hao, Rahman, H.N. Ashiqur, Liu, Yanjun, Pasula, Satish, Tessneer, Kandice L., Cai, Xiaofeng, Liu, Xiaolei, Chang, Baojun, McManus, John, Hahn, Scott, Dong, Jiali, Brophy, Megan L., Yu, Lili, Song, Kai, Silasi-Mansat, Robert, Saunders, Debra, Njoku, Charity, Song, Hoogeun, Mehta-D’Souza, Padmaja, Towner, Rheal, Lupu, Florea, McEver, Rodger P., Xia, Lijun, Boerboom, Derek, Srinivasan, R. Sathish, Chen, Hong
Publicado no J Clin Invest (2015)

Motif mimetic of epsin perturbs tumor growth and metastasis

Por Dong, Yunzhou, Wu, Hao, Rahman, H.N. Ashiqur, Liu, Yanjun, Pasula, Satish, Tessneer, Kandice L., Cai, Xiaofeng, Liu, Xiaolei, Chang, Baojun, McManus, John, Hahn, Scott, Dong, Jiali, Brophy, Megan L., Yu, Lili, Song, Kai, Silasi-Mansat, Robert, Saunders, Debra, Njoku, Charity, Song, Hoogeun, Mehta-D’Souza, Padmaja, Towner, Rheal, Lupu, Florea, McEver, Rodger P., Xia, Lijun, Boerboom, Derek, Srinivasan, R. Sathish, Chen, Hong
Publicado no J Clin Invest (2016)