Selective Targeting of a Novel Epsin-VEGFR2 Interaction Promotes VEGF-Mediated Angiogenesis

RATIONALE: We previously reported that VEGF-induced binding of VEGFR2 to epsins 1 and 2 triggers VEGFR2 degradation and attenuates VEGF signaling. The epsin ubiquitin interacting motif (UIM) was shown to be required for the interaction with VEGFR2, however the molecular determinants that govern how...

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Publicado no:Circ Res
Main Authors: Rahman, H. N. Ashiqur, Wu, Hao, Dong, Yunzhou, Pasula, Satish, Wen, Aiyun, Sun, Ye, Brophy, Megan L., Tessneer, Kandice L., Cai, Xiaofeng, McManus, John, Chang, Baojun, Kwak, Sukyoung, Rahman, Negar S., Xu, Wenjia, Fernandes, Conrad, Mcdaniel, John Michael, Xia, Lijun, Smith, Lois, Srinivasan, R. Sathish, Chen, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4798882/
https://ncbi.nlm.nih.gov/pubmed/26879230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.307679
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