Selective Targeting of a Novel Epsin-VEGFR2 Interaction Promotes VEGF-Mediated Angiogenesis

RATIONALE: We previously reported that VEGF-induced binding of VEGFR2 to epsins 1 and 2 triggers VEGFR2 degradation and attenuates VEGF signaling. The epsin ubiquitin interacting motif (UIM) was shown to be required for the interaction with VEGFR2, however the molecular determinants that govern how...

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Veröffentlicht in:Circ Res
Hauptverfasser: Rahman, H. N. Ashiqur, Wu, Hao, Dong, Yunzhou, Pasula, Satish, Wen, Aiyun, Sun, Ye, Brophy, Megan L., Tessneer, Kandice L., Cai, Xiaofeng, McManus, John, Chang, Baojun, Kwak, Sukyoung, Rahman, Negar S., Xu, Wenjia, Fernandes, Conrad, Mcdaniel, John Michael, Xia, Lijun, Smith, Lois, Srinivasan, R. Sathish, Chen, Hong
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4798882/
https://ncbi.nlm.nih.gov/pubmed/26879230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.307679
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