Genetic Reduction of VEGFR2 Rescues Aberrant Angiogenesis Caused by Epsin Deficiency

OBJECTIVE: We previously showed that endothelial epsin deficiency causes elevated VEGFR2 and enhanced VEGF signaling, resulting in aberrant tumor angiogenesis and tumor growth in adult mice. However, direct evidence demonstrating that endothelial epsins regulate angiogenesis specifically through VEG...

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Autors principals: Tessneer, Kandice L., Pasula, Satish, Cai, Xiaofeng, Dong, Yunzhou, McManus, John, Liu, Xiaolei, Yu, Lili, Hahn, Scott, Chang, Baojun, Chen, Yiyuan, Griffin, Courtney, Xia, Lijun, Adams, Ralf H., Chen, Hong
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920663/
https://ncbi.nlm.nih.gov/pubmed/24311377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.113.302586
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