Genetic Reduction of VEGFR2 Rescues Aberrant Angiogenesis Caused by Epsin Deficiency

OBJECTIVE: We previously showed that endothelial epsin deficiency causes elevated VEGFR2 and enhanced VEGF signaling, resulting in aberrant tumor angiogenesis and tumor growth in adult mice. However, direct evidence demonstrating that endothelial epsins regulate angiogenesis specifically through VEG...

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Bibliografiske detaljer
Main Authors: Tessneer, Kandice L., Pasula, Satish, Cai, Xiaofeng, Dong, Yunzhou, McManus, John, Liu, Xiaolei, Yu, Lili, Hahn, Scott, Chang, Baojun, Chen, Yiyuan, Griffin, Courtney, Xia, Lijun, Adams, Ralf H., Chen, Hong
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920663/
https://ncbi.nlm.nih.gov/pubmed/24311377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.113.302586
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