Temporal and Spatial Regulation of Epsin Abundance and VEGFR3 Signaling are Required for Lymphatic Valve Formation and Function

Lymphatic valves prevent the backflow of the lymph fluid and ensure proper lymphatic drainage throughout the body. Local accumulation of lymphatic fluid in tissues, a condition called lymphedema, is common in individuals with malformed lymphatic valves. The vascular endothelial growth factor recepto...

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Publicat a:Sci Signal
Autors principals: Liu, Xiaolei, Pasula, Satish, Song, Hoogeun, Tessneer, Kandice L., Dong, Yunzhou, Hahn, Scott, Yago, Tadayuki, Brophy, Megan, Chang, Baojun, Cai, Xiaofeng, Wu, Hao, McManus, John, Ichise, Hirotake, Georgescu, Constantin, Wren, Jonathan D., Griffin, Courtney, Xia, Lijun, Srinivasan, R. Sathish, Chen, Hong
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226761/
https://ncbi.nlm.nih.gov/pubmed/25314967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005413
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