Epsin deficiency promotes lymphangiogenesis through regulation of VEGFR3 degradation in diabetes

Impaired lymphangiogenesis is a complication of chronic complex diseases, including diabetes. VEGF-C/VEGFR3 signaling promotes lymphangiogenesis, but how this pathway is affected in diabetes remains poorly understood. We previously demonstrated that loss of epsins 1 and 2 in lymphatic endothelial ce...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Wu, Hao, Rahman, H.N. Ashiqur, Dong, Yunzhou, Liu, Xiaolei, Lee, Yang, Wen, Aiyun, To, Kim H.T., Xiao, Li, Birsner, Amy E., Bazinet, Lauren, Wong, Scott, Song, Kai, Brophy, Megan L., Mahamud, M. Riaj, Chang, Baojun, Cai, Xiaofeng, Pasula, Satish, Kwak, Sukyoung, Yang, Wenxia, Bischoff, Joyce, Xu, Jian, Bielenberg, Diane R., Dixon, J. Brandon, D’Amato, Robert J., Srinivasan, R. Sathish, Chen, Hong
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6118634/
https://ncbi.nlm.nih.gov/pubmed/30102256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96063
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