The Hexahistidine Motif of Host-Defense Protein Human Calprotectin Contributes to Zinc Withholding and Its Functional Versatility

Human calprotectin (CP, S100A8/S100A9 oligomer, MRP-8/MRP-14 oligomer) is an abundant host-defense protein that is involved in the metal-withholding innate immune response. CP coordinates a variety of divalent first-row transition metal ions, which is implicated in its antimicrobial function, and it...

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Bibliografske podrobnosti
izdano v:J Am Chem Soc
Main Authors: Nakashige, Toshiki G., Stephan, Jules R., Cunden, Lisa S., Brophy, Megan Brunjes, Wommack, Andrew J., Keegan, Brenna C., Shearer, Jason M., Nolan, Elizabeth M.
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5038136/
https://ncbi.nlm.nih.gov/pubmed/27541598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b06845
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