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Human Calprotectin Is an Iron-Sequestering Host-Defense Protein
Human calprotectin (CP) is a metal-chelating antimicrobial protein of the innate immune response. The current working model states that CP sequesters manganese and zinc from pathogens. We report the discovery that CP chelates iron and deprives bacteria of this essential nutrient. Elemental analysis...
Shranjeno v:
| izdano v: | Nat Chem Biol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4575267/ https://ncbi.nlm.nih.gov/pubmed/26302479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1891 |
| Oznake: |
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