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Calcium Ion Gradients Modulate the Zinc Affinity and Antibacterial Activity of Human Calprotectin

Calprotectin (CP) is an antimicrobial protein produced and released by neutrophils that inhibits the growth of pathogenic microorganisms by sequestering essential metal nutrients in the extracellular space. In this work, spectroscopic and thermodynamic metal-binding studies are presented to delineat...

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Autors principals: Brophy, Megan Brunjes, Hayden, Joshua A., Nolan, Elizabeth M.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579771/
https://ncbi.nlm.nih.gov/pubmed/23082970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja307974e
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