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Manganese Binding Properties of Human Calprotectin Under Conditions of High and Low Calcium: X-ray Crystallographic and Advanced EPR Spectroscopic Analysis

The antimicrobial protein calprotectin (CP), a hetero-oligomer of the S100 family members S100A8 and S100A9, is the only identified mammalian Mn(II)-sequestering protein. Human CP uses Ca(II) ions to tune its Mn(II) affinity at a biologically unprecedented hexahistidine site that forms at the S100A8...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Gagnon, Derek M., Brophy, Megan Brunjes, Bowman, Sarah E. J., Stich, Troy A., Drennan, Catherine L., Britt, R. David, Nolan, Elizabeth M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354957/
https://ncbi.nlm.nih.gov/pubmed/25597447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja512204s
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