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Calcium-induced tetramerization and zinc chelation shield human calprotectin from degradation by host and bacterial extracellular proteases

Calprotectin (CP, S100A8/S100A9 oligomer, MRP-8/14 oligomer, calgranulins A and B) is a protein component of the innate immune system that contributes to the metal-withholding response by sequestering bioavailable transition metal ions at sites of infection. Human CP employs Ca(ii) ions to modulate...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Stephan, Jules R., Nolan, Elizabeth M.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763987/
https://ncbi.nlm.nih.gov/pubmed/26925211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc03287c
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