A Dose-Response Study of Antibiotic Resistance in Pseudomonas aeruginosa Biofilms

door Brooun, Alexei, Liu, Songhua, Lewis, Kim
Gepubliceerd in 2000

Purification and Ligand Binding of EmrR, a Regulator of a Multidrug Transporter

door Brooun, Alexei, Tomashek, John J., Lewis, Kim
Gepubliceerd in 1999

Sensory Rhodopsin II Transducer HtrII Is Also Responsible for Serine Chemotaxis in the Archaeon Halobacterium salinarum

door Hou, Shaobin, Brooun, Alexei, Suk Yu, Hyung, Freitas, Tracey, Alam, Maqsudul
Gepubliceerd in 1998

An Archaeal Aerotaxis Transducer Combines Subunit I Core Structures of Eukaryotic Cytochrome c Oxidase and Eubacterial Methyl-Accepting Chemotaxis Proteins

door Brooun, Alexei, Bell, James, Freitas, Tracey, Larsen, Randy W., Alam, Maqsudul
Gepubliceerd in 1998

Reviving B-Factors: Retrospective Normalized B-Factor Analysis of c-ros Oncogene 1 Receptor Tyrosine Kinase and Anaplastic Lymphoma Kinase L1196M with Crizotinib and Lorlatinib

door Johnson, Ted W., Gallego, Rebecca A., Brooun, Alexei, Gehlhaar, Dan, McTigue, Michele
Gepubliceerd in ACS Med Chem Lett (2018)

Engineering of an isolated p110α subunit of PI3Kα permits crystallization and provides a platform for structure-based drug design

door Chen, Ping, Deng, Ya-Li, Bergqvist, Simon, Falk, Matthew D, Liu, Wei, Timofeevski, Sergei, Brooun, Alexei
Gepubliceerd in Protein Sci (2014)

The Crystal Structure of Shikimate Dehydrogenase (AroE) Reveals a Unique NADPH Binding Mode

door Ye, Sheng, von Delft, Frank, Brooun, Alexei, Knuth, Mark W., Swanson, Ronald V., McRee, Duncan E.
Gepubliceerd in 2003

Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors

door Falk, Matthew D., Liu, Wei, Bolaños, Ben, Unsal-Kacmaz, Keziban, Klippel, Anke, Grant, Stephan, Brooun, Alexei, Timofeevski, Sergei
Gepubliceerd in 2014

Homo-dimerization of the PAS-B Domains of Hypoxia-Inducible Factors

door Zhu, Jing, Martinez-Yamout, Maria, Cardoso, Rosa, Yan, Jiangli, Love, Robert A., Grodsky, Neil, Brooun, Alexei, Dyson, H. Jane
Gepubliceerd in 2012

Reviving B-Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase

door Johnson, Ted W., Bolanos, Ben, Brooun, Alexei, Gallego, Rebecca A., Gehlhaar, Dan, Jalaie, Mehran, McTigue, Michele, Timofeevski, Sergei
Gepubliceerd in ACS Med Chem Lett (2018)

Three-dimensional Structure of the EphB2 Receptor in Complex with an Antagonistic Peptide Reveals a Novel Mode of Inhibition

door Chrencik, Jill E., Brooun, Alexei, Recht, Michael I., Nicola, George, Davis, Leila K., Abagyan, Ruben, Widmer, Hans, Pasquale, Elena B., Kuhn, Peter
Gepubliceerd in J Biol Chem (2007)

Remedial Strategies in Structural Proteomics: Expression, Purification and Crystallization of the Vav1/Rac1 Complex

door Brooun, Alexei, Foster, Scott A., Chrencik, Jill E., Chien, Ellen Y.T., Kolatkar, Anand R., Streiff, Markus, Ramage, Paul, Widmer, Hans, Weckbecker, Gisbert, Kuhn, Peter
Gepubliceerd in 2006

Crystal Structures of Active Fully Assembled Substrate- and Product-Bound Complexes of UDP-N-Acetylmuramic Acid:l-Alanine Ligase (MurC) from Haemophilus influenzae

door Mol, Clifford D., Brooun, Alexei, Dougan, Douglas R., Hilgers, Mark T., Tari, Leslie W., Wijnands, Robert A., Knuth, Mark W., McRee, Duncan E., Swanson, Ronald V.
Gepubliceerd in 2003

Crystal Structure of Nonstructural Protein 10 from the Severe Acute Respiratory Syndrome Coronavirus Reveals a Novel Fold with Two Zinc-Binding Motifs

door Joseph, Jeremiah S., Saikatendu, Kumar Singh, Subramanian, Vanitha, Neuman, Benjamin W., Brooun, Alexei, Griffith, Mark, Moy, Kin, Yadav, Maneesh K., Velasquez, Jeffrey, Buchmeier, Michael J., Stevens, Raymond C., Kuhn, Peter
Gepubliceerd in 2006

Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2

door Long, Yicheng, Bolanos, Ben, Gong, Lihu, Liu, Wei, Goodrich, Karen J, Yang, Xin, Chen, Siming, Gooding, Anne R, Maegley, Karen A, Gajiwala, Ketan S, Brooun, Alexei, Cech, Thomas R, Liu, Xin
Gepubliceerd in eLife (2017)

Identification of Cys255 in HIF-1α as a novel site for development of covalent inhibitors of HIF-1α/ARNT PasB domain protein–protein interaction

door Cardoso, Rosa, Love, Robert, Nilsson, Carol L, Bergqvist, Simon, Nowlin, Dawn, Yan, Jiangli, Liu, Kevin K-C, Zhu, Jing, Chen, Ping, Deng, Ya-Li, Dyson, H Jane, Greig, Michael J, Brooun, Alexei
Gepubliceerd in 2012

Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

door Brooun, Alexei, Gajiwala, Ketan S., Deng, Ya-Li, Liu, Wei, Bolaños, Ben, Bingham, Patrick, He, You-Ai, Diehl, Wade, Grable, Nicole, Kung, Pei-Pei, Sutton, Scott, Maegley, Karen A., Yu, Xiu, Stewart, Al E.
Gepubliceerd in Nat Commun (2016)

Structural Basis of Guanine Nucleotide Exchange Mediated by the T-cell Essential Vav1

door Chrencik, Jill E., Brooun, Alexei, Zhang, Hui, Mathews, Irimpan I., Hura, Greg L., Foster, Scott A., Perry, J. Jefferson P., Streiff, Markus, Ramage, Paul, Widmer, Hans, Bokoch, Gary M., Tainer, John, Weckbecker, Gisbert, Kuhn, Peter
Gepubliceerd in 2008

Structures of the CXCR4 chemokine receptor in complex with small molecule and cyclic peptide antagonists

door Wu, Beili, Chien, Ellen Y.T., Mol, Clifford D., Fenalti, Gustavo, Liu, Wei, Katritch, Vsevolod, Abagyan, Ruben, Brooun, Alexei, Wells, Peter, Bi, F. Christopher, Hamel, Damon J., Kuhn, Peter, Handel, Tracy M., Cherezov, Vadim, Stevens, Raymond C.
Gepubliceerd in 2010

Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression

door Hanson, Michael A., Brooun, Alexei, Baker, Kent A., Jaakola, Veli-Pekka, Roth, Chris, Chien, Ellen, Alexandrov, Alexander, Velasquez, Jeffrey, Davis, Leila, Griffith, Mark, Moy, Kin, Ganser-Pornillos, Barbie, Kuhn, Peter, Ellis, Sam, Yeager, Mark, Stevens, Raymond C.
Gepubliceerd in 2007