A Dose-Response Study of Antibiotic Resistance in Pseudomonas aeruginosa Biofilms

le Brooun, Alexei, Liu, Songhua, Lewis, Kim
Foilsithe 2000

Purification and Ligand Binding of EmrR, a Regulator of a Multidrug Transporter

le Brooun, Alexei, Tomashek, John J., Lewis, Kim
Foilsithe 1999

Sensory Rhodopsin II Transducer HtrII Is Also Responsible for Serine Chemotaxis in the Archaeon Halobacterium salinarum

le Hou, Shaobin, Brooun, Alexei, Suk Yu, Hyung, Freitas, Tracey, Alam, Maqsudul
Foilsithe 1998

An Archaeal Aerotaxis Transducer Combines Subunit I Core Structures of Eukaryotic Cytochrome c Oxidase and Eubacterial Methyl-Accepting Chemotaxis Proteins

le Brooun, Alexei, Bell, James, Freitas, Tracey, Larsen, Randy W., Alam, Maqsudul
Foilsithe 1998

Reviving B-Factors: Retrospective Normalized B-Factor Analysis of c-ros Oncogene 1 Receptor Tyrosine Kinase and Anaplastic Lymphoma Kinase L1196M with Crizotinib and Lorlatinib

le Johnson, Ted W., Gallego, Rebecca A., Brooun, Alexei, Gehlhaar, Dan, McTigue, Michele
Foilsithe in ACS Med Chem Lett (2018)

Engineering of an isolated p110α subunit of PI3Kα permits crystallization and provides a platform for structure-based drug design

le Chen, Ping, Deng, Ya-Li, Bergqvist, Simon, Falk, Matthew D, Liu, Wei, Timofeevski, Sergei, Brooun, Alexei
Foilsithe in Protein Sci (2014)

The Crystal Structure of Shikimate Dehydrogenase (AroE) Reveals a Unique NADPH Binding Mode

le Ye, Sheng, von Delft, Frank, Brooun, Alexei, Knuth, Mark W., Swanson, Ronald V., McRee, Duncan E.
Foilsithe 2003

Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors

le Falk, Matthew D., Liu, Wei, Bolaños, Ben, Unsal-Kacmaz, Keziban, Klippel, Anke, Grant, Stephan, Brooun, Alexei, Timofeevski, Sergei
Foilsithe 2014

Homo-dimerization of the PAS-B Domains of Hypoxia-Inducible Factors

le Zhu, Jing, Martinez-Yamout, Maria, Cardoso, Rosa, Yan, Jiangli, Love, Robert A., Grodsky, Neil, Brooun, Alexei, Dyson, H. Jane
Foilsithe 2012

Reviving B-Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase

le Johnson, Ted W., Bolanos, Ben, Brooun, Alexei, Gallego, Rebecca A., Gehlhaar, Dan, Jalaie, Mehran, McTigue, Michele, Timofeevski, Sergei
Foilsithe in ACS Med Chem Lett (2018)

Three-dimensional Structure of the EphB2 Receptor in Complex with an Antagonistic Peptide Reveals a Novel Mode of Inhibition

le Chrencik, Jill E., Brooun, Alexei, Recht, Michael I., Nicola, George, Davis, Leila K., Abagyan, Ruben, Widmer, Hans, Pasquale, Elena B., Kuhn, Peter
Foilsithe in J Biol Chem (2007)

Remedial Strategies in Structural Proteomics: Expression, Purification and Crystallization of the Vav1/Rac1 Complex

le Brooun, Alexei, Foster, Scott A., Chrencik, Jill E., Chien, Ellen Y.T., Kolatkar, Anand R., Streiff, Markus, Ramage, Paul, Widmer, Hans, Weckbecker, Gisbert, Kuhn, Peter
Foilsithe 2006

Crystal Structures of Active Fully Assembled Substrate- and Product-Bound Complexes of UDP-N-Acetylmuramic Acid:l-Alanine Ligase (MurC) from Haemophilus influenzae

le Mol, Clifford D., Brooun, Alexei, Dougan, Douglas R., Hilgers, Mark T., Tari, Leslie W., Wijnands, Robert A., Knuth, Mark W., McRee, Duncan E., Swanson, Ronald V.
Foilsithe 2003

Crystal Structure of Nonstructural Protein 10 from the Severe Acute Respiratory Syndrome Coronavirus Reveals a Novel Fold with Two Zinc-Binding Motifs

le Joseph, Jeremiah S., Saikatendu, Kumar Singh, Subramanian, Vanitha, Neuman, Benjamin W., Brooun, Alexei, Griffith, Mark, Moy, Kin, Yadav, Maneesh K., Velasquez, Jeffrey, Buchmeier, Michael J., Stevens, Raymond C., Kuhn, Peter
Foilsithe 2006

Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2

le Long, Yicheng, Bolanos, Ben, Gong, Lihu, Liu, Wei, Goodrich, Karen J, Yang, Xin, Chen, Siming, Gooding, Anne R, Maegley, Karen A, Gajiwala, Ketan S, Brooun, Alexei, Cech, Thomas R, Liu, Xin
Foilsithe in eLife (2017)

Identification of Cys255 in HIF-1α as a novel site for development of covalent inhibitors of HIF-1α/ARNT PasB domain protein–protein interaction

le Cardoso, Rosa, Love, Robert, Nilsson, Carol L, Bergqvist, Simon, Nowlin, Dawn, Yan, Jiangli, Liu, Kevin K-C, Zhu, Jing, Chen, Ping, Deng, Ya-Li, Dyson, H Jane, Greig, Michael J, Brooun, Alexei
Foilsithe 2012

Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

le Brooun, Alexei, Gajiwala, Ketan S., Deng, Ya-Li, Liu, Wei, Bolaños, Ben, Bingham, Patrick, He, You-Ai, Diehl, Wade, Grable, Nicole, Kung, Pei-Pei, Sutton, Scott, Maegley, Karen A., Yu, Xiu, Stewart, Al E.
Foilsithe in Nat Commun (2016)

Structural Basis of Guanine Nucleotide Exchange Mediated by the T-cell Essential Vav1

le Chrencik, Jill E., Brooun, Alexei, Zhang, Hui, Mathews, Irimpan I., Hura, Greg L., Foster, Scott A., Perry, J. Jefferson P., Streiff, Markus, Ramage, Paul, Widmer, Hans, Bokoch, Gary M., Tainer, John, Weckbecker, Gisbert, Kuhn, Peter
Foilsithe 2008

Structures of the CXCR4 chemokine receptor in complex with small molecule and cyclic peptide antagonists

le Wu, Beili, Chien, Ellen Y.T., Mol, Clifford D., Fenalti, Gustavo, Liu, Wei, Katritch, Vsevolod, Abagyan, Ruben, Brooun, Alexei, Wells, Peter, Bi, F. Christopher, Hamel, Damon J., Kuhn, Peter, Handel, Tracy M., Cherezov, Vadim, Stevens, Raymond C.
Foilsithe 2010

Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression

le Hanson, Michael A., Brooun, Alexei, Baker, Kent A., Jaakola, Veli-Pekka, Roth, Chris, Chien, Ellen, Alexandrov, Alexander, Velasquez, Jeffrey, Davis, Leila, Griffith, Mark, Moy, Kin, Ganser-Pornillos, Barbie, Kuhn, Peter, Ellis, Sam, Yeager, Mark, Stevens, Raymond C.
Foilsithe 2007